What is PDRN Salmon DNA?
PDRN (polydeoxyribonucleotide) is a substance derived from salmon DNA that has been purified for medical use. It is biocompatible with human skin and is being studied for its potential regenerative and skin-repairing properties.
How does it work?
- PDRN is extracted, purified, and prepared for use in clinical settings.
- It may support skin repair by interacting with fibroblast cells, which play a role in collagen and tissue regeneration.
- Treatment involves a series of small injections into the skin (dermis) using a fine needle or cannula, typically targeting areas such as the face, under eyes, neck, or hands.
Potential Considerations
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May help improve the appearance of thin or crepey skin
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May support collagen and elastin production
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May provide hydration and improve skin quality
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May have anti-inflammatory properties
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Individual outcomes vary; some patients report improvement in texture or pigmentation
| TIME IN OFFICE | ANESTHESIA | PAIN | INITIAL TREATMENT | MAINTENANCE | SEE RESULTS WHEN? | RESULTS LAST? |
|---|---|---|---|---|---|---|
| Approx. 30–45 min | Topical | Varies by individual | Some individuals notice changes after 1 session; often recommended as a series of 2–3 treatments | Every ~3 months, depending on individual plan | Some individuals may see improvement within 2–3 weeks | Up to ~6 months (varies by individual) |
.PDRN History & Research
PDRN (polydeoxyribonucleotide) has been studied in the context of regenerative medicine since the 1980s. In aesthetic practice, it is being explored for its potential to support skin quality. Clinical research has focused on its possible roles in hydration, texture, and overall skin appearance. Individual outcomes vary.
In 2000s, PDRN gained popularity in aesthetics medicine for its skin benefits: skin hydration, elasticity, reduction in crepiness, fine lines, wrinkles, healing in scarring
Is PDRN safe?
PDRN is generally well tolerated when administered by trained medical professionals. Suitability and safety depend on individual health factors and must be determined through consultation with a licensed provider
Potential Areas for PDRN Treatment
- Full face
- Under eye
- Perioral (around mouth)
- Nasolabial
- Neck
- Hands
- Decollatage/chest
- Stretch marks + scars
- Knees + elbows
| COST FULL FACE | COST FOR UNDER EYE | DOWNTIME | INITIAL TREATMENT | MAINTENANCE | WHEN CAN I SEE RESULTS? |
|---|---|---|---|---|---|
| $480 | $400 | Typically allow 1 day of rest; mild bumps or swelling may occur | Some patients may notice changes after 1 session; a series of 2–3 treatments is often recommended for more noticeable outcomes | Every 3 months (varies by individual and treatment goals) | Some patients may see early changes right away; more visible improvements may develop gradually over 2–3 weeks |
RECOVERY TIME:
Small bumps at the injection site are common and represent localized deposits of product. These usually resolve within hours to a day, though timing varies by individual. Areas with thinner skin, such as under the eye, may show bumps more prominently compared to thicker skin like the cheeks
What are the bumps?
Tiny deposits of PDRN into the localized areas
What causes bigger bumps vs smaller bumps:
Areas with thinner skin (e.g. around the eye) are more likely to have noticeable bumps.
Thicker skin such as the cheeks tends to show less.
PDRN (polydeoxyribonucleotide) is a medical treatment that must be administered by a licensed prescriber. Suitability, dosing, and results vary between individuals. The use of PDRN for aesthetic purposes is not specifically approved by Health Canada and is considered off-label. Outcomes cannot be guaranteed.
